A middle-aged husband's life changes dramatically when his wife asks him for a divorce. He seeks to rediscover his manhood with the help of a newfound friend, Jacob, learning to pick up girls at bars.

A good-natured womanizer and a serial cheater form a platonic relationship that helps reform them in ways, while a mutual attraction sets in.

In 1990s Pittsburgh, a medicine peddler starts a relationship with a young woman suffering from Parkinson's disease.

Composer Peter Bretter (Jason Segel) is in a five-year relationship with actress Sarah Marshall (Kristen Bell), who stars in a ''CSI: Crime Scene Investigation''-like television show titled ''Crime Scene: Scene of the Crime''. One day, as Peter stands stark naked in their apartment, Sarah announces that she is breaking up with him. Devastated, and unable to banish his grief through one-night stands, Peter takes a trip to Hawaii. However, the vacation is ruined when he learns that Sarah and her new rock star boyfriend Aldous Snow (Russell Brand) are also guests of the resort. Taking pity on him, hotel concierge Rachel (Mila Kunis) offers him an expensive suite for free in exchange for cleaning up the room himself.

When Carrie's big step forward in her relationship goes awry, best friends Charlotte, Miranda and Samantha are there to help her pick up the pieces.

Solène, a 40-year-old single mom, begins an unexpected romance with 24-year-old Hayes Campbell, the lead singer of August Moon, the hottest boy band on the planet.

Pete and Debbie are both about to turn 40, their kids hate each other, both of their businesses are failing, they're on the verge of losing their house, and their relationship is threatening to fall apart.

A young man who works as a Bar Mitzvah party host strikes up a friendship with a mother and her autistic daughter.

Alison Scott, a career-minded single woman meets slacker Ben Stone at a local nightclub. After a night of drinking, they end up pregnant and together the two must deal with the repercussions.

As a CODA (Child of Deaf Adults) Ruby is the only hearing person in her deaf family. When the family's fishing business is threatened, Ruby finds herself torn between pursuing her passion at Berklee College of Music and her fear of abandoning her parents.

A teenage girl's secret love letters are exposed and wreak havoc on her love life.

A hard-partying high school senior's philosophy on life changes when he meets the not-so-typical nice girl.

An acclaimed writer, his ex-wife, and their teenaged children come to terms with the complexities of love in all its forms over the course of one tumultuous year.

Movie star Vincent Chase, together with his boys Eric, Turtle, and Johnny, are back - and back in business with super agent-turned-studio head Ari Gold on a risky project that will serve as Vince's directorial debut.

Having both coincidentally cheated death on the same day, estranged twins reunite with the possibility of mending their relationship.

The chronicles of four years in the life of Julie, a young woman who navigates the troubled waters of her love life and struggles to find her career path, leading her to take a realistic look at who she really is.

15-year-old Oliver Tate has two objectives: to lose his virginity before his next birthday, and to extinguish the flame between his mother and an ex-lover who has resurfaced in her life.